METHODOLOGY

The Cortex Protocol:
Architectures of Consciousness

A synergistic triad of chemical, electrical, and atmospheric interventions designed to force-quit the Default Mode Network.

The Scientific Mandate: Conventional psychiatry attempts to "manage" symptoms through chronic medication. The Cortex Institute approaches mental rigidity as a hardware problem. By combining localized glutamatergic surges with electro-magnetic guidance and hyper-oxygenation, we induce a state of "Transient Hypofrontality" effectively resetting the brain's executive control center. This is not therapy. This is neural engineering.

The Synergistic Triad

FIG 1.0: INTEGRATED SYSTEM DYNAMICS

PHASE 1: BIOCHEMICAL DISRUPTION

Ketamine Infusion

Target: NMDA Receptor Complex

We utilize precision-dosed racemic Ketamine to act as a non-competitive antagonist at the NMDA receptor site. This blockade triggers a paradoxical surge of Glutamate—the brain's primary excitatory neurotransmitter.

This surge activates AMPA receptors, initiating the mTOR signaling pathway, which leads to rapid synaptogenesis (the growth of new dendritic spines) in the prefrontal cortex. Subjectively, this dissolves the "ego" or rigid self-narrative, allowing patients to view their trauma from a dispassionate, third-person perspective.

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NMDA Receptor Blockade
Simulation: Ligand Binding Status: Antagonism Active
rTMS Targeting Scan
Target: Left DLPFC Coords: -40, 32, 28
PHASE 2: ELECTRIC GUIDANCE

rTMS (Theta Burst)

Target: Left Dorsolateral Prefrontal Cortex

Once the brain is "primed" by Ketamine, it is in a state of heightened plasticity. Repetitive Transcranial Magnetic Stimulation (rTMS) allows us to "write" new functional patterns into this pliable tissue.

We use Intermittent Theta-Burst Stimulation (iTBS)—a protocol specifically designed to mimic the brain's natural learning rhythm. By applying targeted magnetic pulses to the DLPFC, we strengthen executive control and dampen the overactive limbic system responsible for anxiety and fight-or-flight loops.

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PHASE 3: ATMOSPHERIC PRESERVATION

Hyperbaric Oxygen

Target: Systemic Inflammation

Neurogenesis is metabolicall expensive. To support the rapid growth of new neural tissue, the brain requires vast amounts of energy and oxygen.

Our monoplace Hyperbaric Oxygen Therapy (HBOT) chambers pressurize the patient to 1.3-2.0 ATA while breathing 100% pure oxygen. This dissolves oxygen directly into the blood plasma (Henry's Law), bypassing red blood cells and saturating hypoxic neural tissue. This dramatically reduces neuro-inflammation and accelerates the healing of the physical brain structure.

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[ HBOT CHAMBER SCHEMATIC ] 1.5 ATA
Chamber: Sechrist 3600 Pressure: 2.0 ATA